Data on biological systems is being generated at a rate never seen before. The rapidly decreasing cost for data storage, the ability to sequence the human genome quickly and inexpensively, and developments in ultra-resolution imaging and in single cell methodologies are yielding unprecedented amounts of data. This research thrust deals with the analysis of large databases of genomic, metabolomic, and clinical data, in addition to large datasets from the dynamic imaging of biological systems. These powerful approaches to study biological systems, processes and diseases will result in the development of enhanced diagnoses, treatment, and preventative care targeted to single individuals (personalized medicine).